Dan Fay points to a paper in The Architecture Journal detailing the configuration of an HPC cluster using Windows CCS and a bunch of other MS technology for a solution that focuses on workflow. From the article
…Microsoft Cluster Compute Server Edition is easy to include as a service gateway inside a general n-tier application structure, and is simple to integrate via command-line or API hooks.
Other available technologies can provide the basis for an HPC solution. In particular, Windows Workflow Foundation is well-suited to provide an application interface to CCS, because the features and extensibility of WF, such as persistence and tracking, lend themselves to the requirements of HPC-based solutions. The use of WF also opens up the available choices of user-experience technologies to be applied in a given domain.