Our in-depth series on Intel architects continues with this profile of Mark Seager, a key driver in the company’s mission to achieve Exascale performance on real applications. “Creating and incentivizing an exascale program is huge. Yet more important, in Mark’s view, NCSI has inspired agencies to work together to spread the value from predictive simulation. In the widely publicized Project Moonshot sponsored by Vice President Biden, the Department of Energy is sharing codes with the National Institutes of Health to simulate the chemical expression pathway of genetic mutations in cancer cells with exascale systems.”