BIGstack 2.0 incorporates our latest Intel Xeon Scalable processors, Intel 3D NAND SSD, and Intel FPGAs while also leveraging the latest genomic tools from the Broad Institute in GATK 3.8 and GATK 4.0. This new stack provides a 3.34x speed up in whole genome analysis and a 2.2x daily throughput increase. It is able to deliver these performance improvements with a cost of just $5.68 per whole genome analyzed. The result: researchers will be able to analyze more genomes, more quickly and at lower cost, enabling new discoveries, new treatment options, and faster diagnosis of disease.