We are pleased to offer our readers a Livestream of the HPC Inspires Plenary from SC18 in Dallas. “Simulation and modeling along with AI are being applied to some of our most challenging global threats and humanitarian crises. The SC18 plenary session will explore the capacity of HPC to help mitigate human suffering and advance our capacity to protect the most vulnerable, identify methods to produce enough food globally and ensure the safety of our planet and natural resources.”