In this video from the Stanford HPC Conference, Surya Sanjay and Tanay Bhangale from Troy High School in Michigan describe how their proposal on combatting prion-based disease resulted in their first experiences with HPC at the Stanford High Performance Computing Center. “Using a model of the infectious murine prion and many mutagenized variants of the benign murine prion as PrPX, created with Rosetta’s ab initio software, we plan to perform molecular dynamics (MD) simulations with GROMACS 2020 to determine the success of models based on the described criteria.”