Adam Riesselman from Insitro gave this talk at DOE CSGF 2019. “Biology is quickly becoming a data-driven discipline, in which thousands of biological hypotheses can be answered in a single test tube. I will first highlight the technologies that have enabled this revolution. I will then discuss these advances in the context of understanding natural genetic variation with computational models and their application in predicting the effects of mutations and designing new sets of sequences with desirable properties.”